|
KMID : 1161420130160010026
|
|
Journal of Medicinal Food
2013 Volume.16 No. 1 p.26 ~ p.33
|
|
|
Dandelion Leaf Extract Protects Against Liver Injury Induced by Methionine- and Choline-Deficient Diet in Mice
|
|
Davaatseren Munkhtugs
Hur Haeng-Jeon
Yang Hye-Jeong
Hwang Jin-Taek
Park Jae-Ho
Kim Hyun-Jin
Kim Myung-Sunny
Kim Min-Jung
Kwon Dae-Young
Sung Mi-Jeong
|
|
|
Abstract
|
|
|
|
We investigated the hepatoprotective effects of the extract of dandelion leaves (EDL) on a murine model of methionine- and choline-deficient (MCD) diet-induced nonalcoholic steatohepatitis (NASH). C57BL/6?mice were fed for 4 weeks with one of the following diets: control diet (Cont), MCD diet (MCD), MCD diet supplemented with EDL at 200?mg/kg body weight·daily (MCD+D200), and MCD diet supplemented with EDL at 500?mg/kg body weight·daily (MCD+D500). Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-α and IL-6; and levels of caspase-3 and pJNK/JNK protein. Histopathological evaluations revealed that addition of EDL to the MCD diet dampens the severity of the clinical signs of NASH. Moreover, EDL led to a significant decrease in the serum levels of ALT, hepatic TG, and MDA, and in the expression levels of TNF-α, and IL-6; on the contrary, the levels of reduced GSH increased. At the post-transcriptional level, EDL significantly decreased the activation of procaspase-3 to active caspase-3, and the phosphorylation of JNK. These results suggest that the beneficial effects of EDL on NASH are mainly due to its antioxidant and anti-inflammatory activities.
|
|
|
KEYWORD
|
|
|
fatty liver, hepatotoxicity, inflammation, oxidative stress, Taraxacum officinale
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|